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祝贺张兴国和张小红老师指导研究生在ORGANIC & BIOMOLECULAR CHEMISTRY上发表学术论文 | |||
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日期:2018-03-20阅读:232次 | |||
标题:Palladium-catalyzed dimerization of N-aryl propargylamines for the synthesis of 3-vinylquinolines Abstact:A straightforward method for the synthesis of polyfunctionalized quinolines from readily available N-aryl propargylamines under aerobic conditions was developed. It provides convenient access to a variety of synthetically and pharmaceutically important quinolines in moderate to good yields. Control experiments suggest that the cascade reaction might proceed via the Pd-catalyzed electrophilic cyclization of N-aryl propargylamines followed by a hydroarylation process through trapping of the σ-quinolinylpalladium intermediate with a second molecule of the substrate.
原文链接: //doi.org/10.1039/c8ob00133b
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