新澳门六合彩资料

新澳门六合彩资料

祝贺陈久喜和程天行老师指导研究生在ORGANIC & BIOMOLECULAR CHEMISTRY上发表学术论文

添加时间:2017年09月28日 浏览:

标题:Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles

AbstactAn efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles

原文:新澳门六合彩资料C7OB00572E